Synthesis and degradation of erythrocyte metallothionein in cadmium-administered mice

The origin of erythrocyte metallothionein (MT) in cadmium (Cd) administered mice and its fate were studied in connection with erythrocyte kinetics. It was shown that Cd-MT in the erythrocyte is synthesized in the precursor cells of the erythropoietic tissues, and Cd-MT containing erythrocytes come i...

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Bibliographic Details
Published inExperientia. Supplementum Vol. 52; p. 525
Main Authors Tanaka, K, Min, K, Onosaka, S, Fukuhara, C
Format Journal Article
LanguageEnglish
Published Switzerland 1987
Subjects
Animals
Cadmium - pharmacokinetics
Cadmium - pharmacology
Cadmium Radioisotopes
Chromatography, Gel
Erythrocyte Aging
Erythrocytes - drug effects
Erythrocytes - metabolism
Erythropoiesis
Hematopoietic Stem Cells - metabolism
Kidney - metabolism
Kinetics
Liver - metabolism
Male
Metallothionein - blood
Metallothionein - metabolism
Mice
Spleen - drug effects
Spleen - metabolism
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Summary:The origin of erythrocyte metallothionein (MT) in cadmium (Cd) administered mice and its fate were studied in connection with erythrocyte kinetics. It was shown that Cd-MT in the erythrocyte is synthesized in the precursor cells of the erythropoietic tissues, and Cd-MT containing erythrocytes come into the circulation after maturation. In regard to the degradation, it was found that Cd-MT is stable in the erythrocyte, but decomposed in the spleen or liver with the breakdown of erythrocyte when its life span is over.
ISSN:0071-335X
DOI:10.1007/978-3-0348-6784-9_53