Immunological investigation of late cerebral vasospasm in subarachnoid hemorrhage. (Part 1)

Although the occurrence of so-called late cerebral vasospasm after subarachnoid hemorrhage (SAH) due to ruptured cerebral aneurysm is well-known, its etiology still remains obscure. This time, the authors investigated the etiology by immunological research. Following results were obtained, Out of 13...

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Published inNō shinkei geka Vol. 14; no. 4; p. 493
Main Authors Shirasaka, A, Amano, Y, Mizutani, T, Takanohashi, M, Hattori, K, Tanoi, C, Ohtaki, K
Format Journal Article
LanguageJapanese
Published Japan 01.03.1986
Subjects
Adult
Aged
B-Lymphocytes - immunology
Female
Humans
Intracranial Aneurysm - complications
Ischemic Attack, Transient - immunology
Leukocyte Count
Lymphocyte Activation
Lymphocytes - immunology
Male
Middle Aged
Mitogens - pharmacology
Subarachnoid Hemorrhage - complications
T-Lymphocytes - immunology
Tuberculin Test
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Summary:Although the occurrence of so-called late cerebral vasospasm after subarachnoid hemorrhage (SAH) due to ruptured cerebral aneurysm is well-known, its etiology still remains obscure. This time, the authors investigated the etiology by immunological research. Following results were obtained, Out of 13 cases of SAH due to ruptured cerebral aneurysm, angiographic cerebral vasospasm was observed in 9 cases. In these 9 cases, tendency of decrease in the number of peripheral blood T lymphocytes, depression on the lymphocyte PHA (phytohemagglutinin) and Con A (concanavalin A) response, and tuberculin anergy were found. These results suggest that the depression of cell-mediated immunity function might induce the occurrence of so-called late cerebral vasospasm after SAH.
ISSN:0301-2603
1882-1251