Erythrocyte invasion by malaria (Plasmodium falciparum) merozoites: recent advances in the evaluation of receptor sites

Recent advances in the understanding of the cellular, biochemical and molecular aspects of the highly specific interactions between P. falciparum merozoites and human red blood cells are summarized. Special attention is given to glycophorins A, B and C as receptors of invasion and to the role of car...

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Bibliographic Details
Published inBehring Institute Mitteilungen no. 76; p. 121
Main Authors Hermentin, P, Enders, B
Format Journal Article
LanguageEnglish
Published Germany 01.11.1984
Subjects
Animals
Antigens
Antigens, Protozoan - isolation & purification
Binding Sites
Carbohydrates - blood
Erythrocytes - parasitology
Glycophorin - immunology
Glycophorin - physiology
Humans
Malaria - blood
Malaria - parasitology
Plasmodium falciparum - physiology
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Summary:Recent advances in the understanding of the cellular, biochemical and molecular aspects of the highly specific interactions between P. falciparum merozoites and human red blood cells are summarized. Special attention is given to glycophorins A, B and C as receptors of invasion and to the role of carbohydrates and internal domains of glycophorin A, such as the Wrb antigen, as receptor site. Video pictures displaying the liberation of merozoites from schizont-infected red blood cells and the invasion of human erythrocytes by P. falciparum merozoites are also provided.
ISSN:0301-0457