Usefulness of continuous arterial infusion chemotherapy for post operative multiple recurrence and residual hepatocellular carcinoma

Twenty five patients with postoperative multiple recurrence and residual hepatocellular carcinoma received continuous arterial infusion of CDDP and 5-FU via implanted reservoir. For the next five days, 10 mg/body of CDDP and 250 mg/body of 5-FU using arterial infusion were administered. It was disco...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 23; no. 11; p. 1419
Main Authors Yanagi, I, Koga, A, Okuda, K, Nishio, T, Shibata, J, Aso, K, Matuo, H, Nagashima, J, So, H, Nakayama, T
Format Journal Article
LanguageJapanese
Published Japan 01.09.1996
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Cisplatin - administration & dosage
Drug Administration Schedule
Female
Fluorouracil - administration & dosage
Humans
Infusion Pumps, Implantable
Infusions, Intra-Arterial
Liver Neoplasms - drug therapy
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Male
Middle Aged
Neoplasm Recurrence, Local - drug therapy
Neoplasm, Residual
Postoperative Period
Survival Rate
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Summary:Twenty five patients with postoperative multiple recurrence and residual hepatocellular carcinoma received continuous arterial infusion of CDDP and 5-FU via implanted reservoir. For the next five days, 10 mg/body of CDDP and 250 mg/body of 5-FU using arterial infusion were administered. It was discontinued for two days as one course, and 4 courses were basally administered. The efficacy rate was 60%, and there were 7 (28%) CR (complete response) cases. The survival rate was 76.0% for 1 year and 36.5% for 3 years, which is a favorable result considering their advanced stage. Thus, this treatment seemed to be effective for multiple hepatocellular carcinoma.
ISSN:0385-0684