The most suitable calculation of Kt/V-urea: Kt/V = ln(Ci/Cf)

• Published in: Nihon Jinzo Gakkai shi Vol. 35; no. 1; pp. 59 - 64
• Main Authors: Yanai, M, Albouze, G, Calamai, M, Testou, D, Jungers, P, Takahashi, S, Man, N K
• Format: Journal Article
• Language: English
• Published: Japan 01.01.1993
• Subjects: Aged; Dialysis; Female; Humans; Kinetics; Male; Mathematics; Middle Aged; Models, Biological; Urea - blood
• ISSN: 0385-2385
• DOI: 10.14842/jpnjnephrol1959.35.59

Although various simplified calculation formulae of Kt/V-urea based on urea kinetic modeling have been reported, all the formulae include errors such as post-dialysis urea rebound and urea generation during a dialysis session. In the present study, in order to calculate the precise Kt/V-urea, a formula of Kt/V-urea, taking into account post-dialysis plasma urea rebound and urea generation during a dialysis session (Kt/V-P) was proposed, and compared to other formulae already published, in 49 dialysis patients without residual renal function (26 M and 23 F; mean age, 65 +/- 2 years; mean dialysis duration, 70 +/- 7 mos). The precise post-dialysis plasma urea concentration was significantly higher than the actually measured post-dialysis plasma urea concentration by approximately 12%, and Kt/V-P corresponded to Kt/V-urea = ln(Ci/Cf) with the best correlation in the formulae utilized in the present study, around 1 of Kt/V-urea, which is clinically the most important range. It is concluded that Kt/V-urea = ln(Ci/Cf) is the most suitable formula for the calculation of Kt/V-urea, when post-dialysis plasma urea rebound and urea generation during a dialysis session are taken into account.