Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity

Whole body irradiation of rats (10 Gy as five fractions) found to produce lung fibrosis within 2 months as seen from increased lung collagen hydroxyproline and histopathology. Oral administration of antioxidants curcumin, ellagic acid, bixin and alpha-tocopherol at a concentration 200 mumole/kg body...

Full description

Saved in:
Bibliographic Details
Published inIndian journal of experimental biology Vol. 34; no. 9; p. 845
Main Authors Thresiamma, K C, George, J, Kuttan, R
Format Journal Article
LanguageEnglish
Published India 01.09.1996
Subjects
Animals
Antioxidants - pharmacology
Carotenoids - pharmacology
Curcumin - pharmacology
Ellagic Acid - pharmacology
Lipid Peroxidation - radiation effects
Male
Pulmonary Fibrosis - etiology
Radiation Injuries, Experimental - prevention & control
Radiation-Protective Agents - pharmacology
Rats
Rats, Wistar
Online AccessGet more information

Cover

More Information
Summary:Whole body irradiation of rats (10 Gy as five fractions) found to produce lung fibrosis within 2 months as seen from increased lung collagen hydroxyproline and histopathology. Oral administration of antioxidants curcumin, ellagic acid, bixin and alpha-tocopherol at a concentration 200 mumole/kg body weight significantly reduced the lung collagen hydroxyproline in these animals. In serum and liver lipid peroxidation which were found to be increased by irradiation was reduced significantly by antioxidant treatment. The liver superoxide dismutase and glutathione peroxidase activity were also found to be increased and catalase activity decreased in irradiated control. Superoxide dismutase activity reduced significantly by antioxidant treatment while catalase activity was found to be increased with alpha-tocopherol treatment. The increased frequency of micronucleated polychromatic erythrocytes after whole body irradiation of mice was found to be significantly reduced with antioxidants.
ISSN:0019-5189