Effect of diamide (azodicarboxylic acid-bis-dimethylamide) on arachidonic acid release from human blood platelet phospholipids

It was found that the thiol-oxidizing agent diamide inhibits the formation of arachidonic acid metabolites in thrombin-stimulated platelets. An inhibition of arachidonic acid release from membrane phospholipids in diamide-treated platelets is concluded since diamide does not diminish the formation o...

Full description

Saved in:
Bibliographic Details
Published inFolia haematologica (Leipzig, Germany : 1928) Vol. 111; no. 6; p. 769
Main Authors Lösche, W, Michel, E, Thielmann, K, Till, U
Format Journal Article
LanguageEnglish
Published Germany 1984
Subjects
Arachidonic Acid
Arachidonic Acids - blood
Azo Compounds - pharmacology
Blood Platelets - drug effects
Blood Platelets - enzymology
Cyclooxygenase Inhibitors
Diamide - pharmacology
Fatty Acids, Unsaturated - blood
Glutathione - blood
Humans
Hydroxyeicosatetraenoic Acids - blood
Lipoxygenase Inhibitors
Oxidation-Reduction
Phospholipases - metabolism
Phospholipids - blood
Platelet Aggregation - drug effects
Thrombin - pharmacology
Thromboxane B2 - blood
Online AccessGet more information

Cover

More Information
Summary:It was found that the thiol-oxidizing agent diamide inhibits the formation of arachidonic acid metabolites in thrombin-stimulated platelets. An inhibition of arachidonic acid release from membrane phospholipids in diamide-treated platelets is concluded since diamide does not diminish the formation of stable metabolites from exogenous arachidonic acid. The role of the cellular thiol-disulfide status for the activities of phospholipases involved in arachidonic acid release is discussed.
ISSN:0323-4347