Extra-adrenal pheochromocytoma-ganglioneuroma. A case report

A case of rare extra-adrenal tumor composed of pheochromocytoma-ganglioneuroma which developed in a 48-year-old Japanese male is reported. Histologically, the tumor contained equal proportion of two distinct patterns, pheochromocytoma and ganglioneuroma. Immunohistochemical examination revealed that...

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Bibliographic Details
Published inPathology, research and practice Vol. 188; no. 8; p. 1098
Main Authors Yoshimi, N, Tanaka, T, Hara, A, Bunai, Y, Kato, K, Mori, H
Format Journal Article
LanguageEnglish
Published Germany 01.12.1992
Subjects
Ganglioneuroma - chemistry
Ganglioneuroma - pathology
Ganglioneuroma - ultrastructure
Humans
Male
Middle Aged
Pheochromocytoma - chemistry
Pheochromocytoma - pathology
Pheochromocytoma - ultrastructure
Phosphopyruvate Hydratase - analysis
Retroperitoneal Neoplasms - chemistry
Retroperitoneal Neoplasms - pathology
Retroperitoneal Neoplasms - ultrastructure
S100 Proteins - analysis
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Summary:A case of rare extra-adrenal tumor composed of pheochromocytoma-ganglioneuroma which developed in a 48-year-old Japanese male is reported. Histologically, the tumor contained equal proportion of two distinct patterns, pheochromocytoma and ganglioneuroma. Immunohistochemical examination revealed that pheochromocytoma cells were positive for Leu-7 and ganglion cells in ganglioneuroma were positive for vasoactive intestinal peptide (VIP), respectively. Neuron specific enolase (NSE) was positive in the neoplastic cells of both components, and S-100 protein was also positive in fibers around ganglion cells. Ultrastructural examination revealed that neurosecretory granules were present in the neoplastic cells.
ISSN:0344-0338
DOI:10.1016/S0344-0338(11)81261-6