Mitotic activity and chromosomal findings in lymph nodes from patients with carcinoma or non-Hodgkin's lymphoma

We studied the chromosomal constitution of lymph node cells from two patients with non-Hodgkin's lymphoma, one patient with Crohn's disease, and four patients with carcinoma, using regional lymph nodes that microscopically did not contain metastatic tumor. No consistent chromosomal abnorma...

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Bibliographic Details
Published inBollettino dell'Istituto sieroterapico milanese Vol. 66; no. 2; p. 153
Main Authors Ballaban, K, Grodman, H, Spiers, A
Format Journal Article
LanguageEnglish
Published Italy 1987
Subjects
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Carcinoma - genetics
Carcinoma - pathology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Cells, Cultured
Chromosomes - analysis
Female
Humans
Karyotyping
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Lymph Nodes - pathology
Lymphatic Metastasis - pathology
Metaphase
Mitosis
Vulvar Neoplasms - genetics
Vulvar Neoplasms - pathology
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Summary:We studied the chromosomal constitution of lymph node cells from two patients with non-Hodgkin's lymphoma, one patient with Crohn's disease, and four patients with carcinoma, using regional lymph nodes that microscopically did not contain metastatic tumor. No consistent chromosomal abnormalities were detected and normal metaphases were predominant. We also studied the mitotic activity of lymph node cell suspensions from six patients with carcinomas. Mitoses were always more abundant after 3-4 days in culture, and were consistently higher in cultures to which phytohemagglutinin had not been added. No mitotic activity was seen in lymph nodes that histologically were shown to contain metastatic carcinoma. Possible implications of these findings are discussed.
ISSN:0021-2547