Inhibition of cytokinesis by lead (Pb2+) in a centric diatom

Effect of inorganic and organo lead has been studied on the mitosis of a centric diatom Cyclotella meneghiniana f. unipunctata. Binucleate cells were formed in the presence of different concentrations of Pb2+ (1.0, 2.0, 3.0 and 5.0 mM) due to inhibition of cell plate formation. Lead at 5.0 mM concen...

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Bibliographic Details
Published inIndian journal of experimental biology Vol. 30; no. 3; p. 201
Main Authors Giri, B S, Devi, N A
Format Journal Article
LanguageEnglish
Published India 01.03.1992
Subjects
Cell Division - drug effects
Dose-Response Relationship, Drug
Eukaryota - drug effects
Lead - pharmacology
Nitrates - pharmacology
Tetraethyl Lead - pharmacology
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Summary:Effect of inorganic and organo lead has been studied on the mitosis of a centric diatom Cyclotella meneghiniana f. unipunctata. Binucleate cells were formed in the presence of different concentrations of Pb2+ (1.0, 2.0, 3.0 and 5.0 mM) due to inhibition of cell plate formation. Lead at 5.0 mM concentration was more inhibitory than the other concentrations. Organo lead was a powerful depressant of cytokinesis than inorganic lead. Failure of cytokinesis might be due to disruption of microtubules. Formation of distinct nuclei delayed post incubation cell divisions suggest partial damage of mitotic spindles.
ISSN:0019-5189