Ultrastructural study of peripheral lymphocytes and polymorphonuclear leukocytes in children with lysosomal enzymopathies and hyperlipoproteinemia

On the basis of electronmicroscopic examinations of the peripheral lymphocytes and polymorphonuclear leukocytes (PMNL) in mucopolysaccharidosis of types I and II in Gaucher and Nieman-Pick diseases, in metachromatic leukodystrophy and in hyperlipoproteinemia, the ultrastructural characteristics are...

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Bibliographic Details
Published inActa paediatrica Hungarica Vol. 28; no. 3-4; p. 163
Main Authors László, A, Karcsú, S, Havass, Z
Format Journal Article
LanguageEnglish
Published Hungary 1987
Subjects
Child
Gaucher Disease - pathology
Humans
Hyperlipoproteinemia Type II - pathology
Leukodystrophy, Metachromatic - pathology
Lymphocytes - ultrastructure
Microscopy, Electron
Mucopolysaccharidosis I - pathology
Mucopolysaccharidosis II - pathology
Neutrophils - ultrastructure
Niemann-Pick Diseases - pathology
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Summary:On the basis of electronmicroscopic examinations of the peripheral lymphocytes and polymorphonuclear leukocytes (PMNL) in mucopolysaccharidosis of types I and II in Gaucher and Nieman-Pick diseases, in metachromatic leukodystrophy and in hyperlipoproteinemia, the ultrastructural characteristics are described. Pathological findings with vacuoles formations were observed in Gaucher disease and in metachromatic leukodystrophy against the preliminary literature. The ultrastructural pathological changes are reported from the first ultrastructural PMNL examinations in hyperlipoproteinemias. Electronmicroscopic analysis of the leukocytes is considered to give information equivalent in value to that from liver biopsy studies, but is advantageous in view of its non-invasive nature.
ISSN:0231-441X