Neuropathological findings in a case of chronic inflammatory polyneuropathy

A 52-year-old woman presented with increasing pain, weakness, and paraesthesiae of four months' duration in the lower limbs. She suffered from chronic obstructive airways disease and hypertension. Neurological examination revealed wasting of the quadriceps muscles, weakness of the lower limbs,...

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Bibliographic Details
Published inClinical and experimental neurology Vol. 21; p. 165
Main Authors Milder, D G, Rail, D H, Broe, G A
Format Journal Article
LanguageEnglish
Published Australia 1985
Subjects
Brain - pathology
Chronic Disease
Demyelinating Diseases - pathology
Female
Humans
Lymphocytes - immunology
Middle Aged
Nerve Degeneration
Nerve Fibers - pathology
Polyneuropathies - pathology
Spinal Cord - pathology
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Summary:A 52-year-old woman presented with increasing pain, weakness, and paraesthesiae of four months' duration in the lower limbs. She suffered from chronic obstructive airways disease and hypertension. Neurological examination revealed wasting of the quadriceps muscles, weakness of the lower limbs, and absent ankle jerks. The sensory examination was normal. Full blood count, ESR, biochemical, immunological, and viral studies, urinary heavy metal assays, and cerebrospinal fluid examination were normal. Nerve conduction studies were consistent with a sensorimotor neuropathy, and electromyographic sampling was consistent with acute denervation. A sural nerve biopsy showed axonal degeneration and segmental demyelination. One month after admission, she developed carbon dioxide retention. Her weakness spread to affect the upper limbs, and she could not be resuscitated after a cardiac arrest three months after admission. General autopsy examination revealed bronchopneumonia. Neuropathological examination showed a lymphocytic infiltrate in the nerve roots of the cauda equina, the lumbosacral plexus, and the sural and vagal nerves. Increased cellularity and collagen were evident in these nerves. A diagnosis of chronic inflammatory polyneuropathy was made. The neuropathology of this entity is discussed.
ISSN:0196-6383