Alteration by procaine of spectrin cross-links, deformability, and fluidity related properties of the erythrocyte membrane

The study on procainized human erythrocytes revealed a) temperature dependent changes of cellshapes, b) a significant increase of deformability, c) low amounts of cross-linked membrane proteins, d) a mean cell volume identical with the volume of nonprocainized cells, e) severe reduction of induced a...

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Bibliographic Details
Published inFolia haematologica (Leipzig, Germany : 1928) Vol. 107; no. 3; p. 472
Main Authors Geyer, G, Halbhuber, K J, Stibenz, D, Scheven, C, Unger, J, Benser, A, Fröber, R, Makovitzky, J, Geiling, D, Geiling, H G
Format Journal Article
LanguageEnglish
Published Germany 1980
Subjects
Adhesiveness
Erythrocyte Membrane - drug effects
Erythrocyte Membrane - physiology
Erythrocyte Volume - drug effects
Erythrocytes - cytology
Erythrocytes - drug effects
Hemagglutination - drug effects
Humans
Membrane Fluidity - drug effects
Membrane Proteins - metabolism
Procaine - pharmacology
Spectrin - metabolism
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Summary:The study on procainized human erythrocytes revealed a) temperature dependent changes of cellshapes, b) a significant increase of deformability, c) low amounts of cross-linked membrane proteins, d) a mean cell volume identical with the volume of nonprocainized cells, e) severe reduction of induced anisotropy, f) no loss of negatively charged groups of the glycocalyx, g) decrease of electrophoretic velocity, h) a significant rise of adhesiveness to glass, and i) increase of agglutinability with antiserum and lectin. The findings are discussed in their relationships to alterations of the molecular structure of the red cell membrane.
ISSN:0323-4347