Relationship between vascular endothelial growth factors and advanced glycation end products in the human vitreous

The relation between vascular endothelial growth factor (VEGF) and advanced glycation end product (AGE) is considered a primary factor in the development of diabetic retinopathy. Regarding the relation between VEGF in the vitreous body and pentosidine, an AGE, we compared a diabetic (DM) group (7 ey...

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Bibliographic Details
Published inNippon Ganka Gakkai zasshi Vol. 102; no. 7; p. 442
Main Authors Hashimoto, H, Arai, K, Chikuda, M, Obara, Y
Format Journal Article
LanguageJapanese
Published Japan 01.07.1998
Subjects
Adult
Arginine - analogs & derivatives
Arginine - analysis
Arginine - physiology
Cytokines - secretion
Diabetic Retinopathy - etiology
Diabetic Retinopathy - metabolism
Disease Progression
Endothelial Growth Factors - analysis
Endothelial Growth Factors - physiology
Glycation End Products, Advanced - analysis
Glycation End Products, Advanced - physiology
Humans
Lymphokines - analysis
Lymphokines - physiology
Lysine - analogs & derivatives
Lysine - analysis
Lysine - physiology
Middle Aged
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Vitreous Body - metabolism
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Summary:The relation between vascular endothelial growth factor (VEGF) and advanced glycation end product (AGE) is considered a primary factor in the development of diabetic retinopathy. Regarding the relation between VEGF in the vitreous body and pentosidine, an AGE, we compared a diabetic (DM) group (7 eyes) with a nondiabetic (nonDM) group (7 eyes), and investigated the correlation between VEGF and pentosidine by calculating the correlation coefficient. Levels of both VEGF and pentosidine were significantly higher in the DM group (p < 0.01, p < 0.05), and a positive correlation was observed between the levels of VEGF and pentosidine (r = 0.770, p < 0.001). Since it is clear that there is a relation between VEGF and pentosidine in the vitreous body, we speculated that AGE is related to the secretion of cytokine in patients with diabetic retinopathy, and that it affects the development and progression of the disease.
ISSN:0029-0203