The effects of neocarzinostatin on superoxide production by monocyte-derived macrophages

Monocyte-derived macrophages (M phi) from cancer patients injected with low doses of Neocarzinostatin (NCS, 500 units/day, three times a week) 12 times produced significantly more superoxide (O2-) than controls. Lymphocyte functions, such as PHA response, surface marker and serum IAP, before and aft...

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Bibliographic Details
Published inGan no rinsho. Japan journal of cancer clinics Vol. 32; no. 4; p. 387
Main Authors Ouchi, E, Honnda, I, Wakui, A, Kikuchi, K, Ishida, N
Format Journal Article
LanguageJapanese
Published Japan 01.04.1986
Subjects
Antibiotics, Antineoplastic - pharmacology
Colonic Neoplasms - immunology
Colonic Neoplasms - metabolism
Humans
In Vitro Techniques
Interferon Type I - pharmacology
Lymphocyte Activation
Lymphocytes - classification
Macrophages - metabolism
Monocytes
Neoplasm Proteins - analysis
Stomach Neoplasms - immunology
Stomach Neoplasms - metabolism
Superoxides - metabolism
Zinostatin - pharmacology
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Summary:Monocyte-derived macrophages (M phi) from cancer patients injected with low doses of Neocarzinostatin (NCS, 500 units/day, three times a week) 12 times produced significantly more superoxide (O2-) than controls. Lymphocyte functions, such as PHA response, surface marker and serum IAP, before and after NCS injections were the same. M phi from normal persons cultured with NCS (0.4 microgram/ml) for three days produced more O2- than controls, but those cultured with rINF gamma did not. These results suggest that the increased O2- production of M phi from patients taking low doses of NCS may be due to the direct action of NCS on the M phi.
ISSN:0021-4949