Interconnection of demyelination processes and inflammation in the dynamics of experimental allergic encephalomyelitis

Using a new method for the simultaneous demonstration of myelin breakdown products and cell elements in the demyelinated nervous tissue, a number of previously unknown regularities were revealed concerning interconnection between demyelination processes and inflammation in the dynamics of experiment...

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Bibliographic Details
Published inActa morphologica Hungarica Vol. 36; no. 3-4; p. 155
Main Authors Khizhnyak, M G, Zhitnukhin, Y L, Konovalov, G V, Semenov, S P
Format Journal Article
LanguageEnglish
Published Hungary 1988
Subjects
Animals
Brain - pathology
Demyelinating Diseases - pathology
Encephalomyelitis, Autoimmune, Experimental - pathology
Guinea Pigs
Histocytochemistry
Myelin Sheath - pathology
Spinal Cord - pathology
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Summary:Using a new method for the simultaneous demonstration of myelin breakdown products and cell elements in the demyelinated nervous tissue, a number of previously unknown regularities were revealed concerning interconnection between demyelination processes and inflammation in the dynamics of experimental allergic encephalomyelitis (EAE). Alterations in osmophilia and in size of myelin breakdown products in the demyelination foci are demonstrated to be the most essential in the EAE pathomorphology, a certain type of cellular reaction corresponding to each stage of periaxonal changes. A close relationship was found between demyelination processes and inflammation which determines the structure of the demyelination foci at various stages of the disease.
ISSN:0236-5391