The role of the extracellular matrix in tumor cell metastasis

The extracellular matrix is a macromolecular network that surrounds cells and makes up a significant portion of their microenvironment. During the processes of invasion and metastasis, tumor cells encounter interstitial stroma and basement membranes many times. In fact, tumor cell response to extrac...

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Bibliographic Details
Published inIn vivo (Athens) Vol. 8; no. 1; p. 49
Main Authors Stracke, M L, Murata, J, Aznavoorian, S, Liotta, L A
Format Journal Article
LanguageEnglish
Published Greece 01.01.1994
Subjects
Animals
Cell Adhesion
Cell Division
Cell Movement
Extracellular Matrix - pathology
Extracellular Matrix - physiology
Humans
Neoplasm Invasiveness
Neoplasm Metastasis - pathology
Neoplasms - pathology
Neoplasms - physiopathology
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Summary:The extracellular matrix is a macromolecular network that surrounds cells and makes up a significant portion of their microenvironment. During the processes of invasion and metastasis, tumor cells encounter interstitial stroma and basement membranes many times. In fact, tumor cell response to extracellular matrix components appears to be a major determinant of metastatic potential.
ISSN:0258-851X