Effect of treatment on cyclosporine- and nifedipine-induced gingival enlargement: clinical and histologic results

The clinical and histologic responses to periodontal treatment of gingival enlargements, induced when cyclosporine and nifedipine were administered singly or in combination, were evaluated. A significant correlation was noted between plaque, gingivitis, and gingival overgrowth. Severity of enlargeme...

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Bibliographic Details
Published inThe International journal of periodontics & restorative dentistry Vol. 18; no. 1; p. 80
Main Authors Santi, E, Bral, M
Format Journal Article
LanguageEnglish
Published United States 01.02.1998
Subjects
Adult
Aged
Anti-Infective Agents, Local - therapeutic use
Chlorhexidine - therapeutic use
Combined Modality Therapy
Cyclosporine - adverse effects
Dental Scaling
Drug Therapy, Combination
Gingival Hyperplasia - chemically induced
Gingival Hyperplasia - pathology
Gingival Hyperplasia - therapy
Gingivectomy
Humans
Immunosuppressive Agents - adverse effects
Male
Mouthwashes - therapeutic use
Nifedipine - adverse effects
Surgical Flaps
Vasodilator Agents - adverse effects
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Summary:The clinical and histologic responses to periodontal treatment of gingival enlargements, induced when cyclosporine and nifedipine were administered singly or in combination, were evaluated. A significant correlation was noted between plaque, gingivitis, and gingival overgrowth. Severity of enlargement appeared to be greater in patients on combined therapy. All treatment approaches such as scaling, root planning, gingivectomy, and periodontal flaps, and a combination of therapies, were effective in the management of gingival overgrowth up to 1 year after completion of treatment. Adjunctive use of chlorhexidine was found to be beneficial.
ISSN:0198-7569