Long-term treatment of pulmonary tuberculosis with ofloxacin in a subject with liver cirrhosis

We report on the clinical case of a patient suffering from active pulmonary tuberculosis associated with liver cirrhosis, which limited the use of the major antituberculosis drugs. The patient was treated with a 12 month ofloxacin and ethambutol therapy. At completion of the therapy, the lung cavity...

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Bibliographic Details
Published inMonaldi archives for chest disease Vol. 50; no. 4; p. 279
Main Authors Bagnato, G F, Di Cesare, E, Gulli, S, Cucinotta, D
Format Journal Article
LanguageEnglish
Published Italy 01.08.1995
Subjects
Administration, Oral
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - adverse effects
Anti-Infective Agents - therapeutic use
Antitubercular Agents - administration & dosage
Antitubercular Agents - adverse effects
Antitubercular Agents - therapeutic use
Ethambutol - administration & dosage
Ethambutol - adverse effects
Ethambutol - therapeutic use
Follow-Up Studies
Humans
Liver Cirrhosis, Alcoholic - complications
Male
Middle Aged
Ofloxacin - administration & dosage
Ofloxacin - adverse effects
Ofloxacin - therapeutic use
Tuberculosis, Pulmonary - drug therapy
Uric Acid - blood
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Summary:We report on the clinical case of a patient suffering from active pulmonary tuberculosis associated with liver cirrhosis, which limited the use of the major antituberculosis drugs. The patient was treated with a 12 month ofloxacin and ethambutol therapy. At completion of the therapy, the lung cavity disappeared with a considerable reduction of the lung infiltration, as seen in the chest radiograph. At the same time, a positive to negative conversion of the sputum was noted. The only significant side-effect was hyperuricaemia.
ISSN:1122-0643