Immunohistochemical study of chronic ulcerative colitis by use of monoclonal antibody Hb3 against human large bowel carcinoma

Monoclonal antibody Hb3 against large bowel carcinoma was used to study 20 cases of large bowel carcinoma and 60 cases of chronic ulcerative colitis (CUC) by immunohistochemical methods. The positive Hb3 binding rates to large bowel carcinoma, CUC, normal bowel mucosa and fetal large bowel mucosa we...

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Bibliographic Details
Published inZhonghua bing li xue za zhi Vol. 22; no. 4; p. 221
Main Author Kuang, X W
Format Journal Article
LanguageChinese
Published China 01.08.1993
Subjects
Adenocarcinoma - immunology
Adolescent
Adult
Aged
Antibodies, Monoclonal - analysis
Antigens, Tumor-Associated, Carbohydrate - immunology
Child
Colitis, Ulcerative - immunology
Colonic Neoplasms - immunology
Colonic Neoplasms - pathology
Female
Humans
Immunohistochemistry
Intestinal Mucosa - immunology
Male
Middle Aged
Precancerous Conditions - immunology
Precancerous Conditions - pathology
Rectal Neoplasms - immunology
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Summary:Monoclonal antibody Hb3 against large bowel carcinoma was used to study 20 cases of large bowel carcinoma and 60 cases of chronic ulcerative colitis (CUC) by immunohistochemical methods. The positive Hb3 binding rates to large bowel carcinoma, CUC, normal bowel mucosa and fetal large bowel mucosa were 80.0%, 41.7%, 8.3% and 100.0% respectively. In addition, the positive Hb3 binding rate to CUC in the rectum was higher than that in the colon, which agrees with the fact that most large bowel carcinomas are found in the rectum. The authors believe that the expression of tumor associated antigen in CUC is a very early biochemical abnormality which can be detected before morphological changes occur. The results of this study support the viewpoint that chronic ulcerative colitis is a precancerous condition of large bowel cancer.
ISSN:0529-5807