Age-dependent responsiveness of T lymphocytes to allogeneic and PHA stimulation

In the course of family investigations a linear age-dependent decrease of reactivity against pooled allogeneic lymphocytes was found between 20 and 70 yr of age. This decreasing tendency was ascertained also by the investigation of unrelated people of a more advanced age. In the elderly, maximal tra...

Full description

Saved in:
Bibliographic Details
Published inThymus Vol. 1; no. 4-5; p. 205
Main Authors Onody, C, Bátory, G, Patrányi, G G
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.1980
Subjects
Adult
Aged
Aging
Antigens
Dose-Response Relationship, Immunologic
Female
Humans
Lymphocyte Activation
Male
Middle Aged
Phytohemagglutinins - pharmacology
T-Lymphocytes - immunology
Online AccessGet more information

Cover

More Information
Summary:In the course of family investigations a linear age-dependent decrease of reactivity against pooled allogeneic lymphocytes was found between 20 and 70 yr of age. This decreasing tendency was ascertained also by the investigation of unrelated people of a more advanced age. In the elderly, maximal transformation values in PHA stimulation investigated at different PHA doses showed a similar degree of reduction as allogeneic reactivity, and a good correlation between the two parameters of T-lymphocyte function has been found.
ISSN:0165-6090