Induction of microsomal drug metabolizing enzymes by phenobarbitone in the rats exposed to increased environmental temperature

Exposure of rats for 3 consecutive days (6 h a day) to 28 degrees C or 35 degrees C does not lead to changes in the induction of hepatic microsomal cytochrome P-450 associated monooxygenases by phenobarbitone as compared with control animals exposed to 21 degrees C. These results suggest that enviro...

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Bibliographic Details
Published inActa Poloniae pharmaceutica Vol. 48; no. 3-4; p. 35
Main Authors Pachecka, J, Kobylińska, K, Zasłona, H, Zagdańska, B, Bicz, W
Format Journal Article
LanguageEnglish
Published Poland 1991
Subjects
Animals
Environmental Exposure
Enzyme Induction - drug effects
Heating
Male
Microsomes, Liver - drug effects
Microsomes, Liver - enzymology
Mixed Function Oxygenases - biosynthesis
Phenobarbital - pharmacology
Rats
Rats, Inbred Strains
Stimulation, Chemical
Temperature
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Summary:Exposure of rats for 3 consecutive days (6 h a day) to 28 degrees C or 35 degrees C does not lead to changes in the induction of hepatic microsomal cytochrome P-450 associated monooxygenases by phenobarbitone as compared with control animals exposed to 21 degrees C. These results suggest that environmental temperature does not change the capacity of phenobarbitone to induce drug metabolizing enzymes in rat liver.
ISSN:0001-6837