Excess of factor X antigen versus clotting counterpart in coumarin treated patients as determined by an Elisa method

Factor X antigen was assayed by means of an Elisa (sandwich) method in 36 patients on long-term anticoagulant therapy. The average value observed was 31.4% +/- 12.2. In almost every instance the antigen level was higher than the clotting counterpart (14.4% +/- 4.5). In a few instances no major diffe...

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Bibliographic Details
Published inFolia haematologica (Leipzig, Germany : 1928) Vol. 112; no. 2; p. 326
Main Authors Girolami, A, Vicarioto, M A, Ruzza, G, Vergolani, A, Boeri, G
Format Journal Article
LanguageEnglish
Published Germany 1985
Subjects
Antigens - analysis
Enzyme-Linked Immunosorbent Assay - methods
Factor X - analysis
Factor X - immunology
Humans
Immunoenzyme Techniques
Warfarin - therapeutic use
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Summary:Factor X antigen was assayed by means of an Elisa (sandwich) method in 36 patients on long-term anticoagulant therapy. The average value observed was 31.4% +/- 12.2. In almost every instance the antigen level was higher than the clotting counterpart (14.4% +/- 4.5). In a few instances no major difference was noted between factor X antigen and factor X activity. The method correlated fairly well with other immunological methods (electroimmunoassay and Laser Nephelometer). Therefore, factor X Elisa method appears to be a suitable method for factor X antigen evaluation.
ISSN:0323-4347