A mathematical model for the effect of red light penetration depth on tumor growth

The effect of different local temperature increase in normal and tumorous tissue, influenced by red light commonly used in photodynamic therapy, on tumor growth rate was reanalyzed, taking into account the tumor tissue penetration depth of the light used. The rear part of the tumor is definitely not...

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Bibliographic Details
Published inActa medica Croatica Vol. 50; no. 3; p. 119
Main Authors Svarc, A, Jurin, M, Borović, S, Zorc, H, Doko, M
Format Journal Article
LanguageEnglish
Published Croatia 1996
Subjects
Animals
Female
Fibrosarcoma - chemically induced
Fibrosarcoma - pathology
Fibrosarcoma - therapy
Hyperthermia, Induced
Male
Mice
Mice, Inbred Strains
Models, Biological
Models, Theoretical
Neoplasm Transplantation
Phototherapy
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Summary:The effect of different local temperature increase in normal and tumorous tissue, influenced by red light commonly used in photodynamic therapy, on tumor growth rate was reanalyzed, taking into account the tumor tissue penetration depth of the light used. The rear part of the tumor is definitely not receiving the same light dose, and consequently the same amount of heat energy, as the front part. The effect is taken into account by using a mathematical model of tumor growth for the rear part of the tumor. Positive experimental results of hyperthermia due to the energy deposited by the red light, are more encouraging after such a correction than previously reported.
ISSN:1330-0164
1848-8897