Effect of indomethacin on desoxycorticosterone acetate-sodium chloride-induced renal lesions in the pregnant rat and her offspring

• Published in: Developmental pharmacology and therapeutics Vol. 1; no. 4; p. 229
• Main Authors: Parks, B R, Douglas, B H, Weaver, M M, Gillespie, J E, Davenport, W D, Rawson, J E
• Format: Journal Article
• Language: English
• Published: Switzerland 1980
• Subjects: Animals; Desoxycorticosterone - adverse effects; Female; Hypertension - chemically induced; Hypertension - pathology; Indomethacin - adverse effects; Kidney - pathology; Pregnancy; Pregnancy Complications, Cardiovascular - pathology; Rats; Sodium Chloride - adverse effects
• ISSN: 0379-8305
• DOI: 10.1159/000455540

To explore the effects of inhibition of prostaglandin synthesis on renal lesions, 37 female rats were made hypertensive and of these, 22 were treated with indomethacin. The blood pressure (207 +/- 5 mm Hg) in the indomethacin group was significantly (p < 0.01) higher than the blood pressure (191 +/- 7 mm Hg) in the control group. Weight changes were not significantly different. Renal lesions of varying severity were noted in mothers and offspring of both groups. The lesions ranged from thickening of the basement membranes to glomerular congestion, some with nearly complete eradication of glomerular architecture. Although the lesions appeared to be more marked in the indomethacin-treated group, no specific pattern of lesion location nor significant differences in the severity of the lesions was demonstrated. These data suggest that the lesions noted were the result of the hypertension. However, exacerbation by indomethacin could not be excluded.