Synthesis and immunological activity of mono- and disubstituted derivatives of 2,5-dimercapto-1,3,4-thiodiazoles

It is presented that the newly synthesized mono- and disubstituted 2,5-dimercapto-1,3,4-thiodiazole derivatives exert immunotropic activity. This effect was evaluated by measuring plaque forming cell number, circulating immunoglobulins level, autologous rosette number, mitogenic activity and by perf...

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Published inArchivum Immunologiae et Therapiae Experimentalis Vol. 43; no. 3-4; p. 199
Main Authors Kowalczyk-Bronisz, S H, Pomorski, J, Bubak, B, Pregiel, M, Błaszczyk, B
Format Journal Article
LanguageEnglish
Published Switzerland 1995
Subjects
Animals
Carbamates - chemical synthesis
Female
Immunosuppressive Agents - chemical synthesis
Immunosuppressive Agents - pharmacology
Lethal Dose 50
Lymphocyte Activation - drug effects
Male
Mice
Mice, Inbred BALB C
Rosette Formation
Structure-Activity Relationship
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Summary:It is presented that the newly synthesized mono- and disubstituted 2,5-dimercapto-1,3,4-thiodiazole derivatives exert immunotropic activity. This effect was evaluated by measuring plaque forming cell number, circulating immunoglobulins level, autologous rosette number, mitogenic activity and by performing popliteal lymph node assay. It is shown that intensity of immunotropic activity depends on chemical structure: mono-substituted derivatives had a strong suppressive effect, disubstituted compounds showed the variable activity. One compound of this group exerted a stimulatory effect. The tested compounds were active in popliteal lymph node assay and had no mitogenic activity.
ISSN:0004-069X