Anterior uveitis with ankylosing spondylitis and HLA

We investigated the relationship between anterior uveitis with ankylosing spondylitis (AS) and human leukocyte antigen (HLA) alleles. Forty patients were studied, 19 with anterior uveitis and 21 without it. No deviation in the frequencies of HLA-B27 antigen and related alleles were observed between...

Full description

Saved in:
Bibliographic Details
Published inNippon Ganka Gakkai zasshi Vol. 100; no. 4; p. 292
Main Authors Numaga, J, Islam, M S, Mitsui, H, Maeda, H
Format Journal Article
LanguageJapanese
Published Japan 01.04.1996
Subjects
Alleles
Base Sequence
HLA Antigens - chemistry
HLA Antigens - genetics
HLA-DR Antigens - genetics
HLA-DR Serological Subtypes
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Spondylitis, Ankylosing - complications
Spondylitis, Ankylosing - immunology
Uveitis, Anterior - complications
Uveitis, Anterior - immunology
Online AccessGet more information

Cover

More Information
Summary:We investigated the relationship between anterior uveitis with ankylosing spondylitis (AS) and human leukocyte antigen (HLA) alleles. Forty patients were studied, 19 with anterior uveitis and 21 without it. No deviation in the frequencies of HLA-B27 antigen and related alleles were observed between the two groups of patients. Twelve cases (63.2%) with anterior uveitis had expressed HLA-DR8 (DRB1 0803). On the other hand, only 1 case had expressed the same antigen and this difference was statistically significant (relative risk: 34.3 Pc < 0.007) as we reported previously. We found HLA-DR8 was a candidate for susceptibility to anterior uveitis in AS.
ISSN:0029-0203