11q- and constitutional X trisomy in a patient with M5b acute non-lymphocytic leukemia

A patient with M5b acute nonlymphoblastic leukemia (ANLL) and a 47,XXX del(11) (q23) karyotype is described. Partial remission was obtained after treatment with daunorubicin, arabinosylcytosine and VP-16. Subsequently, two courses of chemotherapy for resistant ANLL were administered without achievin...

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Bibliographic Details
Published inHaematologica (Roma) Vol. 78; no. 3; p. 185
Main Authors Bigazzi, C, Galieni, P, Scarinci, R, Vivarelli, R, Bucalossi, A, Biancolini, G, Falbo, R, Vessichelli, F, Dispensa, E
Format Journal Article
LanguageEnglish
Published Italy 01.05.1993
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Chromosomes, Human, Pair 11
Female
Humans
Karyotyping
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
Middle Aged
Trisomy
X Chromosome
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Summary:A patient with M5b acute nonlymphoblastic leukemia (ANLL) and a 47,XXX del(11) (q23) karyotype is described. Partial remission was obtained after treatment with daunorubicin, arabinosylcytosine and VP-16. Subsequently, two courses of chemotherapy for resistant ANLL were administered without achieving complete remission. Abnormalities of chromosome 11 are typical of M4 and M5 ANLL. X trisomy is one of the most common human aneuploidia; however, correlation with increased incidence of hematological neoplasia has not been described.
ISSN:0390-6078