Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis

The occurrence of anti-double stranded(ds) DNA idiotype 2C10 was studied in patients with mixed connective tissue disease (MCTD) and progressive systemic sclerosis (PSS). The 2C10-idiotype was originally identified on a dsDNA-specific monoclonal antibody from a lupus-prone MRL/Mp-lpr/lpr (MRL/l) mou...

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Bibliographic Details
Published inBulletin of Tokyo Medical and Dental University Vol. 36; no. 2; p. 13
Main Authors Kubota, T, Kanai, Y
Format Journal Article
LanguageEnglish
Published Japan 01.06.1989
Subjects
Animals
Antibodies, Antinuclear - analysis
Antibodies, Monoclonal
Antibody Specificity
Autoimmune Diseases - immunology
DNA - immunology
Humans
Immunoglobulin Idiotypes - analysis
Lupus Erythematosus, Systemic - immunology
Mice
Mice, Inbred Strains
Mixed Connective Tissue Disease - immunology
Scleroderma, Systemic - immunology
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Summary:The occurrence of anti-double stranded(ds) DNA idiotype 2C10 was studied in patients with mixed connective tissue disease (MCTD) and progressive systemic sclerosis (PSS). The 2C10-idiotype was originally identified on a dsDNA-specific monoclonal antibody from a lupus-prone MRL/Mp-lpr/lpr (MRL/l) mouse, and it has been demonstrated to be present in the sera of patients with systemic lupus erythematosus (SLE) as well as MRL/l mice. This study showed that three out of ten patients with MCTD and five out of ten with PSS had higher titers of 2C10-idiotype in their sera than the normal subjects. There was a good correlation between the anti-dsDNA activities and the idiotype levels in MCTD (r = 0.85) but not in PSS (r = -0.38). These results suggest that the 2C10-idiotype-bearing antibodies acquire the dsDNA-binding activity more easily in MCTD than in PSS.
ISSN:0040-8921