The ultrastructural examination of gingival fibromatosis

Hereditary gingival fibromatosis (GF) is a special type of fibrous overgrowth classified as non-inflammatory gingival enlargement. Microscopically, the connective tissue consists of coarse collagen bundles and fibroblasts. The ultrastructural examination of fibrous gingival hyperplasia reveals that...

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Bibliographic Details
Published inJournal of Marmara University Dental Faculty Vol. 2; no. 1; p. 409
Main Authors Noyan, U, Yilmaz, S, Arda, O, Kuru, B
Format Journal Article
LanguageEnglish
Published Turkey 01.09.1994
Subjects
Biopsy
Connective Tissue - ultrastructure
Female
Fibroblasts - ultrastructure
Fibromatosis, Gingival - pathology
Gingiva - ultrastructure
Humans
Male
Mast Cells - ultrastructure
Microscopy, Electron
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Summary:Hereditary gingival fibromatosis (GF) is a special type of fibrous overgrowth classified as non-inflammatory gingival enlargement. Microscopically, the connective tissue consists of coarse collagen bundles and fibroblasts. The ultrastructural examination of fibrous gingival hyperplasia reveals that fibroblasts phagocyte the mast cell granules and mast cells stimulate collagen synthesis which results in hyperplasia. In the ultrastructural examination of phenytoin-induced hyperplasia, fibroblasts, phagocytosing mast cell granules were also found. Based on these findings, the purpose of this study is to establish whether there is a relationship between fibroblasts and mast cells in GF. The gingival tissues of 5 patients with GF were examined ultrastructurally. In the connective tissue, well-defined bundles of collagen fibres were found together with fibroblasts and capillaries. There were mast cells around these capillaries which had collapsed lumens. The proximity of the mast cells and fibroblasts may indicate that mast cells play some role on collagen synthesis of fibroblasts.
ISSN:1018-5992