Effect of gonadotropin-releasing peptide (GRP) on LH secretion of mouse pituitary in vitro

Synthetic GRP and its analogues, GRP-NH2, [Glu7.9.14 Lys6.10] GRP (6-14), [Phe14] GRP (5-14) and [Phe14] GRP, at the concentration of 0.05 mmol.L-1 were shown to have stimulatory effect on LH secretion in cultured mouse pituitary in vitro. The luteotropin releasing activity of GRP and its analogues...

Full description

Saved in:
Bibliographic Details
Published inYao hsüeh hsüeh pao Vol. 29; no. 8; p. 581
Main Authors Wang, N G, Guan, M Z, Wang, D X, Lu, G S
Format Journal Article
LanguageChinese
Published China 1994
Subjects
Abortifacient Agents - chemical synthesis
Abortifacient Agents - pharmacology
Abortion, Induced
Animals
Embryo Implantation - drug effects
Female
Gonadotropin-Releasing Hormone - chemical synthesis
Gonadotropin-Releasing Hormone - pharmacology
Luteinizing Hormone - secretion
Male
Mice
Mice, Inbred ICR
Organ Culture Techniques
Pituitary Gland - secretion
Pregnancy
Online AccessGet more information

Cover

More Information
Summary:Synthetic GRP and its analogues, GRP-NH2, [Glu7.9.14 Lys6.10] GRP (6-14), [Phe14] GRP (5-14) and [Phe14] GRP, at the concentration of 0.05 mmol.L-1 were shown to have stimulatory effect on LH secretion in cultured mouse pituitary in vitro. The luteotropin releasing activity of GRP and its analogues was estimated to be 115.4, 114.2, 140.0, 162.0 and 179.0% of the control group, respectively. Subcutaneous administration of [Phe14] GRP on days 7-9 and 1-5 of pregnancy and [Phe14] GRP (5-14) on days 2-4 of gestation at dosage of 1 mg.d-1 (each mouse) caused fetal death in 40-60% of mice.
ISSN:0513-4870