Differential induction of interleukin-6 production in monocytes, endothelial cells and smooth muscle cells

Studying the production of IL-6 (interleukin-6) by monocytes, endothelial cells and smooth muscle cells we observed that cytokine inducers like IL-1, TNF alpha (tumor necrosis factor alpha), LPS (lipopolysaccharide), SAC (Staphylococcus Aureus Cowan 1) and PMA could be divided roughly into two categ...

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Bibliographic Details
Published inEuropean cytokine network (Montrouge) Vol. 2; no. 2; p. 115
Main Authors Aarden, L, Helle, M, Boeije, L, Pascual-Salcedo, D, de Groot, E
Format Journal Article
LanguageEnglish
Published France 01.03.1991
Subjects
Antigens, Bacterial
Cells, Cultured
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Endotoxins - pharmacology
Enzyme Activation - drug effects
Gene Expression Regulation - drug effects
Humans
Interleukin-6 - biosynthesis
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - metabolism
Lipopolysaccharides
Monokines - biosynthesis
Monokines - pharmacology
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - metabolism
Protein Kinase C - metabolism
Recombinant Proteins - pharmacology
Tetradecanoylphorbol Acetate - pharmacology
Umbilical Veins
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Summary:Studying the production of IL-6 (interleukin-6) by monocytes, endothelial cells and smooth muscle cells we observed that cytokine inducers like IL-1, TNF alpha (tumor necrosis factor alpha), LPS (lipopolysaccharide), SAC (Staphylococcus Aureus Cowan 1) and PMA could be divided roughly into two categories. Bacterial products such as LPS or SAC have a potent IL-6 inducing effect on monocytes and minor or no effect on endothelial- and smooth muscle cells. The other category comprising IL-1, TNF alpha and PMA induces IL-6 production in endothelial- and smooth muscle cells. Only IL-1 induces IL-6 production in monocytes as well as in endothelial cells and smooth muscle cells. In addition to IL-6, also IL-1 and TNF alpha are produced by monocytes however with different kinetics. None of the stimuli had any inhibitory effect on IL-6 production with the exception of PMA. Whereas PMA induced IL-6 production in endothelial cells and it potentiated the induction of IL-6 by IL-1 in these cells, it inhibited LPS-stimulated IL-6 production in monocytes. In line with the effects of PMA, staurosporin induced IL-6 production in monocytes and it inhibited IL-1 driven IL-6 production by endothelial cells.
ISSN:1148-5493