Estimation of integral value of input function for the quantification of cerebral blood flow with 123I-IMP using one-point arterial blood sampling

Cerebral blood flow (CBF) has been measured using a microsphere model with octanol-extracted radioactivity counts (integral value of input function). We developed a new method estimating the integral value of input function. First, we fitted the whole brain time-activity curves early after intraveno...

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Bibliographic Details
Published inKaku igaku Vol. 35; no. 1; p. 7
Main Authors Fujioka, H, Murase, K, Inoue, T, Ishimaru, Y, Akamune, A, Yamamoto, Y, Tanada, S, Ikezoe, J
Format Journal Article
LanguageJapanese
Published Japan 01.01.1998
Subjects
Amphetamines
Blood Specimen Collection
Cerebrovascular Circulation
Cerebrovascular Disorders - diagnosis
Cerebrovascular Disorders - physiopathology
Humans
Iodine Radioisotopes
Iofetamine
Microspheres
Models, Biological
Radiopharmaceuticals
Scintillation Counting
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Summary:Cerebral blood flow (CBF) has been measured using a microsphere model with octanol-extracted radioactivity counts (integral value of input function). We developed a new method estimating the integral value of input function. First, we fitted the whole brain time-activity curves early after intravenous injection of N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) by the least-squares method. Second, we differentiated this equation. Third, we calibrated it using octanol-extracted radioactivity counts of the arterial blood sampled at 5 min. Finally, we integrated it. A significant correlation was found between the integral values obtained using a new method and those obtained using the continuous arterial blood sampling data (y = 1.048x-1206, r = 0.984). The errors between the CBF values obtained using a new method and those obtained using the 5-min continuous arterial blood sampling was 6.88 +/- 4.78%. Measurement of integral values of the input function using a new method with one-point arterial blood sampling is less invasive and convenient, and is not influenced by cardiopulmonary disease or smoking. Therefore, it would be useful for the routine measurement of CBF.
ISSN:0022-7854