Evaluation of Fagara zanthoxyloides root extract in sickle cell anemia blood in vitro

An aqueous extract was prepared from roots of Fagara zanthoxyloides and examined for evidence of an antisickling effect in vitro. Addition of 25 mg/ml of the extract to fresh blood samples from sickle anemia subjects produced no change in the blood oxygen dissociation curves, and approximately equal...

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Bibliographic Details
Published inLloydia Vol. 38; no. 5; p. 387
Main Authors Honig, G R, Farnsworth, N R, Ferenc, C, Vida, L N
Format Journal Article
LanguageEnglish
Published United States 01.09.1975
Subjects
Anemia, Sickle Cell - drug therapy
Erythrocytes, Abnormal - drug effects
Ghana
Humans
Oxygen - blood
Plant Extracts - therapeutic use
Plants, Medicinal - analysis
Ghana
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Summary:An aqueous extract was prepared from roots of Fagara zanthoxyloides and examined for evidence of an antisickling effect in vitro. Addition of 25 mg/ml of the extract to fresh blood samples from sickle anemia subjects produced no change in the blood oxygen dissociation curves, and approximately equal percentages of sickled cells were observed at comparable oxygen saturation levels in the presence or absence of the extract. These observations fail to confirm previous reports describing an antisickling effect of root extracts of Fagara zanthoxyloides.
ISSN:0024-5461