The role of medial medulla in the depressive responses in pulmonary and carotid arteries to injection of acetylcholine at fourth ventricle

The role of medial medulla in the depressive responses in pulmonary and carotid arteries to injection of acetylcholine (ACh) at the fourth ventricle was studied by means of electrolytic destruction and microinjection of drugs at the relevant brain areas. It was found that (1) electrolytic destructio...

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Bibliographic Details
Published inSheng li hsüeh pao Vol. 41; no. 3; p. 291
Main Authors Ni, H, Jing, L X, Shen, S
Format Journal Article
LanguageChinese
Published China 01.06.1989
Subjects
Acetylcholine - pharmacology
Animals
Blood Pressure - drug effects
Carotid Arteries - physiology
Depression, Chemical
Female
Injections, Intraventricular
Male
Medulla Oblongata - physiology
Pulmonary Artery - physiology
Rabbits
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Summary:The role of medial medulla in the depressive responses in pulmonary and carotid arteries to injection of acetylcholine (ACh) at the fourth ventricle was studied by means of electrolytic destruction and microinjection of drugs at the relevant brain areas. It was found that (1) electrolytic destruction of medial medulla significantly diminished the depressive responses to ACh in pulmonary and carotid arteries; (2) destruction of nucleus tractus solitarius (NTS) at the level of the medullary obex did not affect the depressive responses in both arteries; obex did not affect the depressive responses in both arteries; (3) microinjection of 5-hydroxytryptamine (5-HT) blockers, cyproheptadine and 2-bromolysergic acid diethylamide (BOL), into the fourth ventricle or medial medulla could lessen the depressive responses to ACh in pulmonary and carotid arteries; (4) microinjection of naloxone in the same way could partially abolish the depressive responses. It is thus assumed that the ACh-induced depressive responses in
ISSN:0371-0874