Evidence for antibody and immune-complex deposition in heart transplantation: a report of three cases

Immunofluorescence microscopy of endomyocardial biopsy specimens from heart allograft recipients identified immunopathologic changes in three of 17 patients. These changes included immunoglobulin G and complement C3 deposition in tissue structures such as capillary endothelium and basal membranes, c...

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Bibliographic Details
Published inThe Journal of heart and lung transplantation Vol. 11; no. 6; p. 1209
Main Authors Shumakov, V I, Beletskaya, L V, Baranova, F S, Mogilevsky, G M, Chestukhin, V V, Kormer AYa, Kazakov, E N, Khubutia, A S, Kurenkova, L G, Khalimova, Z A
Format Journal Article
LanguageEnglish
Published United States 01.11.1992
Subjects
Biopsy
Complement C3 - analysis
Endocardium - immunology
Endocardium - pathology
Fluorescent Antibody Technique
Graft Rejection - immunology
Graft Rejection - pathology
Heart Transplantation - immunology
Heart Transplantation - pathology
Humans
Immunoglobulin G - analysis
Immunosuppression
Myocardium - immunology
Myocardium - pathology
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Summary:Immunofluorescence microscopy of endomyocardial biopsy specimens from heart allograft recipients identified immunopathologic changes in three of 17 patients. These changes included immunoglobulin G and complement C3 deposition in tissue structures such as capillary endothelium and basal membranes, cardiomyocyte sarcolemma, and interstitial tissue. Moreover, the immunopathologic changes could be correlated with acute cellular rejection episodes evidenced by endomyocardial biopsy criteria.
ISSN:1053-2498