Tumor cell motility

Tumor cell motility is required for invasion and metastasis. The locomotory machinery of the cell includes cell projections called pseudopodia which are regulated by a complicated linkage between cell surface receptors or sensors and the internal cytoskeleton. Recently a new class of motility stimul...

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Bibliographic Details
Published inSeminars in cancer biology Vol. 2; no. 2; p. 111
Main Authors Liotta, L A, Stracke, M L, Aznavoorian, S A, Beckner, M E, Schiffmann, E
Format Journal Article
LanguageEnglish
Published England 01.04.1991
Subjects
Biomarkers, Tumor - physiology
Cell Movement
Chemotaxis
Extracellular Matrix - physiology
Glucose-6-Phosphate Isomerase - physiology
Humans
Insulin-Like Growth Factor I - physiology
Insulin-Like Growth Factor II - physiology
Neoplasm Metastasis - physiopathology
Pseudopodia - physiology
Signal Transduction
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Summary:Tumor cell motility is required for invasion and metastasis. The locomotory machinery of the cell includes cell projections called pseudopodia which are regulated by a complicated linkage between cell surface receptors or sensors and the internal cytoskeleton. Recently a new class of motility stimulating cytokines have been identified. These cytokines can function as autocrine motility factors and require a pertussis toxin sensitive G protein pathway to transduce a random motile response.
ISSN:1044-579X