Plasma renin activity in shock due to aluminium phosphide poisoning

Plasma renin activity (PRA) was estimated in 30 patients with aluminium phosphide (AIP) poisoning (study group) admitted in shock. Ten patients in shock other than due to AIP poisoning (Group II A) and 20 normal healthy subjects (Group II B) served as controls. The PRA was significantly higher in th...

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Bibliographic Details
Published inJournal of the Association of Physicians of India Vol. 38; no. 6; p. 398
Main Authors Chugh, S N, Singhal, H R, Mehta, L, Chugh, K, Shankar, V, Malhotra, K C
Format Journal Article
LanguageEnglish
Published India 01.06.1990
Subjects
Adolescent
Adult
Aluminum Compounds
Child
Dose-Response Relationship, Drug
Female
Humans
Male
Pesticides - administration & dosage
Pesticides - poisoning
Phosphines - administration & dosage
Phosphines - poisoning
Renin - blood
Shock - blood
Shock - chemically induced
Shock - mortality
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Summary:Plasma renin activity (PRA) was estimated in 30 patients with aluminium phosphide (AIP) poisoning (study group) admitted in shock. Ten patients in shock other than due to AIP poisoning (Group II A) and 20 normal healthy subjects (Group II B) served as controls. The PRA was significantly higher in the study group and group II A as compared to normal healthy subjects (p less than 0.001). Significantly higher PRA was found in the study group as compared to Group II A (p less than 0.001). The initial higher PRA continued to rise further in the study group but it started decreasing in Group II A as the duration of shock advanced. Continuation of shock in AIP poisoning was probably due to slow release of toxic PH3 gas, which was detected by positive silver nitrate paper test. The rise in PRA was directly proportional to the dose of pesticide consumed. There was direct relationship of mortality with increased PRA. Angiotensin converting enzyme inhibitors may have a role in combating shock in AIp poisoning.
ISSN:0004-5772