Severe post-vaccination reaction to 17D yellow fever vaccine in Nigeria

An unusual outbreak of post-vaccination reactions to 17D yellow fever vaccine occurred at Shaki, Nigeria, in May 1987. Twenty-five of the affected people were treated at the Baptist Hospital Shaki. The patients presented with rapidly progressing swelling of the left arm with associated fever and oth...

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Bibliographic Details
Published inRevue roumaine de virologie (Bucharest, Romania : 1990) Vol. 45; no. 1-2; p. 25
Main Authors Oyelami, S A, Olaleye, O D, Oyejide, C O, Omilabu, S A, Fatunla, B A
Format Journal Article
LanguageEnglish
Published Romania 01.01.1994
Subjects
Adolescent
Adult
Aged
Child
Child, Preschool
Female
Humans
Male
Middle Aged
Nigeria
Severity of Illness Index
Viral Vaccines - adverse effects
Yellow Fever - prevention & control
Nigeria
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Summary:An unusual outbreak of post-vaccination reactions to 17D yellow fever vaccine occurred at Shaki, Nigeria, in May 1987. Twenty-five of the affected people were treated at the Baptist Hospital Shaki. The patients presented with rapidly progressing swelling of the left arm with associated fever and other constitutional symptoms few hours after inoculation with the vaccine. Some of the patients developed gangrene of the affected limb, five of them went into coma and died. Poor hygiene and improper handling of vaccine as well as contamination of vaccine from the source are possible causes. A review of vaccine delivery strategies especially at local community levels; sound training, supervision of vaccinators and health education are strongly recommended to prevent reoccurrence of similar reactions.
ISSN:1018-0532