Fast modulation of glutamate and GABA receptor--mediate electrophysiological responses by glucocorticoid

Fast modulation by glucocorticoid on gluatmate and GABA receptor-mediated electrophysiological responses was investigated by extracellular iontophoresis and intracellular techniques in rat hypothalamic brain slices and guinea pig coeliac ganglion preparations respectively. The results were as follow...

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Bibliographic Details
Published inSheng li hsüeh pao Vol. 48; no. 6; p. 551
Main Authors Wang, W, Xing, B R, Chen, Y Z
Format Journal Article
LanguageChinese
Published China 01.12.1996
Subjects
Animals
Electrophysiology
Ganglia, Sympathetic - physiology
Guinea Pigs
Hydrocortisone - pharmacology
Hypothalamus - physiology
Male
Neurotransmitter Agents - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, GABA - drug effects
Receptors, GABA - physiology
Receptors, Glutamate - physiology
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Summary:Fast modulation by glucocorticoid on gluatmate and GABA receptor-mediated electrophysiological responses was investigated by extracellular iontophoresis and intracellular techniques in rat hypothalamic brain slices and guinea pig coeliac ganglion preparations respectively. The results were as follows: Glucocorticoid inhibited the glutamate receptor-mediated excitatory response and potentiated the GABA receptor-mediated inhibitory response within 5 min after perfusion. All these responses are reversible after removal of the glucocorticoid. Low Ca2+ high Mg2+ medium was ineffective to block the fast modulatory effects of glucocorticoid on the gluatmate and GABA receptor-mediated responses. It appears that the latter responses are mediated through some non-genomic mechanism without an involvement of synaptic circuitry.
ISSN:0371-0874