The clinical utility of antihistone antibodies. Autoantibodies reactive with chromatin in systemic lupus erythematosus and drug-induced lupus

• Published in: Clinics in laboratory medicine Vol. 17; no. 3; p. 367
• Main Author: Burlingame, R W
• Format: Journal Article
• Language: English
• Published: United States 01.09.1997
• Subjects: Animals; Autoantibodies - analysis; Chromatin - chemistry; Chromatin - immunology; Diagnostic Tests, Routine; Drug-Related Side Effects and Adverse Reactions; Histones - immunology; Humans; Lupus Erythematosus, Systemic - chemically induced; Lupus Erythematosus, Systemic - immunology

Autoantibodies reactive with denatured histones and with epitopes requiring the native histone-DNA structure in chromatin have been measured by many techniques. The presence of antichromatin antibodies is useful in diagnosing systemic lupus erythematosus and in diagnosing lupus induced by procainami...