The clinical utility of antihistone antibodies. Autoantibodies reactive with chromatin in systemic lupus erythematosus and drug-induced lupus

Autoantibodies reactive with denatured histones and with epitopes requiring the native histone-DNA structure in chromatin have been measured by many techniques. The presence of antichromatin antibodies is useful in diagnosing systemic lupus erythematosus and in diagnosing lupus induced by procainami...

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Bibliographic Details
Published inClinics in laboratory medicine Vol. 17; no. 3; p. 367
Main Author Burlingame, R W
Format Journal Article
LanguageEnglish
Published United States 01.09.1997
Subjects
Animals
Autoantibodies - analysis
Chromatin - chemistry
Chromatin - immunology
Diagnostic Tests, Routine
Drug-Related Side Effects and Adverse Reactions
Histones - immunology
Humans
Lupus Erythematosus, Systemic - chemically induced
Lupus Erythematosus, Systemic - immunology
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Summary:Autoantibodies reactive with denatured histones and with epitopes requiring the native histone-DNA structure in chromatin have been measured by many techniques. The presence of antichromatin antibodies is useful in diagnosing systemic lupus erythematosus and in diagnosing lupus induced by procainamide and certain other drugs such as quinidine, isoniazid, sulfasalazine and acebutolol. In contrast, antibodies to denatured histones do not appear to be diagnostically useful at this time.
ISSN:0272-2712
DOI:10.1016/s0272-2712(18)30201-4