Induction of nitric oxide synthase by chlorinated pesticides (p,p'-DDT, chlordane, endosulfan) in rat liver

The aim of this study is to investigate the effect of certain polychlorinated pesticides on the induction of rat liver Ca(2+)-independent nitric oxide synthase (NOS) and compare it with the effect of bacterial lipopolysaccharide. Our results show that endosulfan and p, p'-DDT treatment signific...

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Bibliographic Details
Published inCentral European journal of public health Vol. 4 Suppl; p. 48
Main Authors Dhouib, M, Lugnier, A
Format Journal Article
LanguageEnglish
Published Czech Republic 1996
Subjects
Animals
Liver - enzymology
Nitric Oxide Synthase - biosynthesis
Rats
Rats, Wistar
Transcription, Genetic
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Summary:The aim of this study is to investigate the effect of certain polychlorinated pesticides on the induction of rat liver Ca(2+)-independent nitric oxide synthase (NOS) and compare it with the effect of bacterial lipopolysaccharide. Our results show that endosulfan and p, p'-DDT treatment significantly increases the NOS activity while no significant induction by any route of administration was observed in the case of chlordane. Our results show therefore that a wide variety of chlorinated pesticides, which are considered as hepatic tumor promotors, can stimulate the expression of NO synthase in vivo.
ISSN:1210-7778