Biopharmaceutical investigation of rectal suppositories. Part 2(1): Pharmaceutical and biological availability of phenobarbital and phenobarbital-sodium

The influence of the suppository base and drug solubility on the release an absorption of phenobarbital and phenobarbital-sodium from model suppositories was investigated. It was established that the pharmaceutical and biological availability of phenobarbital is higher from a hydrophilic base becaus...

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Bibliographic Details
Published inPharmazie Vol. 40; no. 4; p. 257
Main Authors Minkov, E, Lambov, N, Kirchev, D, Bantutova, I, Tencheva, J
Format Journal Article
LanguageEnglish
Published Germany 01.04.1985
Subjects
Animals
Biological Availability
Excipients
Intestinal Absorption
Models, Biological
Phenobarbital - administration & dosage
Phenobarbital - blood
Phenobarbital - metabolism
Rabbits
Rectum - metabolism
Solubility
Suppositories
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Summary:The influence of the suppository base and drug solubility on the release an absorption of phenobarbital and phenobarbital-sodium from model suppositories was investigated. It was established that the pharmaceutical and biological availability of phenobarbital is higher from a hydrophilic base because of its improved solubility. The rate and the degree of release of phenobarbital-sodium are more significant from lipophilic bases. The bioavailability of two drug forms-phenobarbital and phenobarbital-sodium--is almost equal after rectal and oral administration.
ISSN:0031-7144