Regulation of neutrophil apoptosis--its biological significance in inflammation and the immune response

Neutrophils play a pivotal role in host defence against bacterial infection. Their life span is short compared with that of leukocytes of other lineages. Neutrophils are programmed to die by apoptosis at the time of differentiation. However, recent studies have demonstrated that environment also has...

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Bibliographic Details
Published inHuman cell : official journal of Human Cell Research Society Vol. 9; no. 3; p. 215
Main Authors Sendo, F, Tsuchida, H, Takeda, Y, Gon, S, Takei, H, Kato, T, Hachiya, O, Watanabe, H
Format Journal Article
LanguageEnglish
Published Japan 01.09.1996
Subjects
Animals
Apoptosis - physiology
Glucocorticoids - physiology
Immunity - physiology
Inflammation - physiopathology
Neutrophils - physiology
Rats
Stress, Psychological
Tumor Necrosis Factor-alpha - physiology
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Summary:Neutrophils play a pivotal role in host defence against bacterial infection. Their life span is short compared with that of leukocytes of other lineages. Neutrophils are programmed to die by apoptosis at the time of differentiation. However, recent studies have demonstrated that environment also has a great influence on apoptosis of these cells. Based on our recent experimental results, we present here a review of studies on the regulation of neutrophil apoptosis and discuss its biological significance in inflammation and the immune response.
ISSN:0914-7470