Protection by N-acetylcysteine of cyclophosphamide metabolism - related in vivo depression of mixed function oxygenase activity and in vitro denaturation of cytochrome P-450

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 93; no. 3; p. 797
Main Authors Berrigan, M J, Gurtoo, H L, Sharma, S D, Struck, R F, Marinello, A J
Format Journal Article
LanguageEnglish
Published United States 14.04.1980
Subjects
Acetylcysteine - pharmacology
Animals
Aryl Hydrocarbon Hydroxylases - metabolism
Benzopyrenes - pharmacology
Cyclophosphamide - metabolism
Cyclophosphamide - pharmacology
Cytochrome P-450 Enzyme System - metabolism
Liver - drug effects
Liver - enzymology
Male
Mixed Function Oxygenases - metabolism
Oxidoreductases - metabolism
Rats
Spectrophotometry
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ISSN:0006-291X
DOI:10.1016/0006-291X(80)91147-X