Differences between the effect of prazosin and lysine-acetylsalicylate on some thermoregulatory parameters in nonfeverish rabbits

Thermoregulatory responses to prazosin and lysine-acetylsalicylate (LAS) were investigated in afebrile rabbits at different ambient temperatures, i.e. at 5, 21 and 28 degrees C. In cold as well as in heat prazosin significantly inhibited the metabolic rate. This effect was accompanied by falls in re...

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Bibliographic Details
Published inPolish journal of pharmacology and pharmacy Vol. 37; no. 6; p. 875
Main Authors Matuszek, M, Szreder, Z, Korolkiewicz, Z
Format Journal Article
LanguageEnglish
Published Poland 01.11.1985
Subjects
Animals
Aspirin - analogs & derivatives
Aspirin - pharmacology
Body Temperature Regulation - drug effects
Carbon Dioxide - metabolism
Lysine - analogs & derivatives
Lysine - pharmacology
Male
Oxygen Consumption - drug effects
Prazosin - pharmacology
Rabbits
Respiration - drug effects
Skin Temperature - drug effects
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Summary:Thermoregulatory responses to prazosin and lysine-acetylsalicylate (LAS) were investigated in afebrile rabbits at different ambient temperatures, i.e. at 5, 21 and 28 degrees C. In cold as well as in heat prazosin significantly inhibited the metabolic rate. This effect was accompanied by falls in rectal temperatures, particularly at the ambient temperature of 5 degrees C. Increases in ear skin temperatures became visible only when this drug was used in rabbits maintained in the thermoneutral environment. On the other hand LAS in all tested conditions indicated a marked metabolic activity associated with an intensified respiratory heat loss. As a consequence, the rabbits responded with slight increases in body temperature. The possible mode of thermoregulatory activity of prazosin is being considered in confrontation with that of LAS.
ISSN:0301-0244