Pharmacokinetics and distribution of a fluoresceinated glycosaminoglycan, sulodexide, in rats. Part II: Organ distribution in rats

Fluorescein-labelled sulodexide tissue distribution was studied in the rat after intravenous administration at the dosage of 15 mg/kg. A globular fluorescence was observed mainly in the extracellular matrix and a diffuse one was present in liver and kidney parenchyma lasting for a long time, up to 4...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 35; no. 10; p. 1517
Main Authors Ruggeri, A, Guizzardi, S, Franchi, M, Morocutti, M, Mastacchi, R
Format Journal Article
LanguageEnglish
Published Germany 1985
Subjects
Animals
Fluorescein
Fluoresceins
Glycosaminoglycans - metabolism
Hypolipidemic Agents - metabolism
Kidney Cortex - metabolism
Kinetics
Lung - metabolism
Male
Rats
Rats, Inbred Strains
Tissue Distribution
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Summary:Fluorescein-labelled sulodexide tissue distribution was studied in the rat after intravenous administration at the dosage of 15 mg/kg. A globular fluorescence was observed mainly in the extracellular matrix and a diffuse one was present in liver and kidney parenchyma lasting for a long time, up to 4 h after administration. In particular in the kidney cortex the fluorescent material was present at the higher time intervals. Fluorescence was also observed in the spleen and in the perivascular areas and in the media of the aortic wall.
ISSN:0004-4172