HLA phenotype frequencies in pulmonary tuberculosis

Susceptibility and/or immune response to tuberculosis may or may not be associated with particular histocompatibility leucocyte antigen (HLA) phenotype frequencies. The present study was undertaken to north eastern Indian population to verify any association between HLA phenotypes and immune respons...

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Bibliographic Details
Published inJournal of the Indian Medical Association Vol. 94; no. 9; p. 328
Main Authors Ghosal, A G, Mandal, T K, Chowdhury, T K, Mukherjee, K, Mukherjee, D
Format Journal Article
LanguageEnglish
Published India 01.09.1996
Subjects
Adolescent
Adult
Case-Control Studies
Disease Susceptibility
Female
Gene Frequency
Histocompatibility Testing
HLA Antigens - genetics
Humans
India
Male
Phenotype
Tuberculosis, Pulmonary - genetics
Tuberculosis, Pulmonary - immunology
India
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Summary:Susceptibility and/or immune response to tuberculosis may or may not be associated with particular histocompatibility leucocyte antigen (HLA) phenotype frequencies. The present study was undertaken to north eastern Indian population to verify any association between HLA phenotypes and immune response to mycobacterial antigen. HLA-typing was done in 60 well Tarasaki trays and T-cell subsets in each group were measured using Ficoll-hypaque nylon wool columns and dynabeads (M-450). No universal association with particular HLA-type and pulmonary tuberculosis has been confirmed.
ISSN:0019-5847