Effect of REM sleep deprivation on the each seizure stage in feline amygdaloid kindling

• Published in: Psychiatria et neurologia Japonica Vol. 96; no. 2; p. 109
• Main Authors: Kawahara, R, Hamazaki, Y, Takeshita, H
• Format: Journal Article
• Language: Japanese
• Published: Japan 1994
• Subjects: Amygdala - physiology; Animals; Arousal - physiology; Cats; Electric Stimulation; Evoked Potentials; Kindling, Neurologic; Seizures - physiopathology; Sleep Deprivation - physiology; Sleep, REM - physiology
• ISSN: 0033-2658

The effect of REM sleep deprivation (RD) on the each seizure stage in feline amygdaloid kindling (AM-K) was studied. RD for 12 hours (12-h RD) was performed by applying the platform procedure at stages 2 and 4, and immediately after RD the triggering threshold of each seizure stage and the duration of after discharge was measured. At stage 6, 12-h and 72-h RD were performed, and the generalized seizure triggering threshold (GST), the duration of after discharge, and the latency to generalized convulsive seizure (LGS) were measured. For the controls, a platform sufficiently large to allow a cat to lie down and sleep was used under the same conditions as those for RD (Non-RD). With the platform procedure employed in this study, the %REM decreased significantly to 2% of what it was before 12-h RD (p < 0.01). After the 12-h RD, the %REM and %S-2 increased significantly compared with those during the RD (p < 0.05-0.01), revealing a rebound phenomenon. After the 12-h RD, the %W-2 also showed a significant decrease (p < 0.05). The results were as follows: (1) The triggering seizure threshold of stage 2 after the 12-h RD showed a significant decrease (p < 0.01). Though the AD duration after RD prolonged than those after Non-RD, significant differences was not noted. (2) The triggering threshold and AD duration of stage 4 after 12-h RD showed no significant change. (3) GST, AD duration, LGS showed no significant change by 12-and 72-h RD. The results of present study led to the following conclusions: At stage 2 of AM-K, REM sleep increased temporarily, and consequently the REM pressure is elevated after RD so much that it lowers the triggering threshold at stage 2 of AM-K. On the other hand, at stages 4 and 6 of AM-K, REM sleep is temporarily decreased, and consequently the REM pressure is not elevated by RD so that the triggering threshold at stages 4 and 6 of AM-K were not lowered.